What Causes Hives to Appear in a Food-Allergic Reaction?

Published: February 24, 2014

Q: Why do we get hives in a food-allergic reaction? And will they always appear?

Dr. Sicherer: Hives, also called urticaria, develop when allergy cells in the skin release chemicals, including histamine, that cause localized swelling, redness and itching. The response looks like a series of mosquito bites, often across an expanse of skin, but various shapes and sizes can occur.

The allergy cells are armed with proteins made by the immune system, called IgE antibodies. The IgE antibodies act like antennae that can detect the food protein to which a person may be allergic. When the IgE comes in contact with the food protein, it alerts the cell to release the chemicals, including histamine.

This chemical release leads to hives, which can occur from direct contact of the food within the deeper layer of the skin (such an intradermal allergy skin test). Or they can result from the proteins being absorbed in the gut, and then circulating in the blood and reaching the cells in the skin.

Hives Do Not Always Happen

It is important to realize that while hives are classic sign of an allergic reaction, they do not always occur during allergic reactions or anaphylaxis.

Indeed, a severe reaction could include gut, breathing or circulation symptoms but no rash. In fact some fatal food-allergic reactions have occurred without hives, with a delay in treatment with epinephrine being attributed, in part, to not recognizing anaphylaxis. The reason? The victim did not have hives.

Dr. Scott Sicherer is a practicing allergist, clinical researcher and professor of pediatrics. He is Director of the Jaffe Food Allergy Institute and Chief of Pediatric Allergy and Immunology at the Icahn School of Medicine at Mount Sinai in New York. He’s also the author of Food Allergies: A Complete Guide for Eating When Your Life Depends On It.

Read more:
When The Cold Brings on Hives
Anaphylaxis Goes Unrecognized

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