Does the Drug Used in Anesthesia Contain Egg and Soy?

Published: February 28, 2020

Q: Our teenage daughter with egg and soy allergies has to have surgery. I’ve been told that the drug propofol used in anesthesia contains both egg and soy. Is that correct and should I be concerned?

A surgeon performing surgery on a patient after receiving anesthesia.

Dr. Sharma: Propofol is mixed in a liquid which contains soybean oil and egg lecithin (a fatty substrate).

For people like your daughter, who have soy or egg allergies, they are allergic to the proteins in these foods, not the oils or fats.

While in theory soy oil and egg lecithin might contain trace amounts of protein, there are no reports in the medical literature of any allergic reactions caused by these ingredients.

Check Specific Case re Propofol

There have been reports of allergic reactions to propofol in medical literature. But none of these appear to be related to soy or egg allergy.

Therefore, the general recommendation is that patients who require anesthesia with soy or egg allergy can receive propofol.

But be sure to check with your daughter’s allergist to discuss her particular case.

Dr. Sharma is an allergist, clinical researcher and associate professor of pediatrics. He is Chief of the Division of Allergy and Immunology at Children’s National Medical Center in Washington D.C. and Director of the Food Allergy Program. He co-authors “The Food Allergy Experts” column in Allergic Living’s e-magazine. Questions submitted will be considered for answer in the e-magazine.

The Truth About Drug Allergies
Top Allergens: Places Where They Hide
Food Allergies and Hospitals: Lack of Training and Reliable Systems

Submit a Question